Infectious embolisation to the central nervous system from endocarditis: analyses of 99 cases

M Karvaj; V Krcmery; E Kalavsky; P Kisac; V Hricak; P Mlkvy; M Kovac; F Bauer; B Rudinsky; M Sramka

Infectious embolisation to the central nervous system from endocarditis: analyses of 99 cases

Neuro Endocrinol Lett. 2007 Jun:28 Suppl 2:47-8.

Authors

M Karvaj¹, V Krcmery, E Kalavsky, P Kisac, V Hricak, P Mlkvy, M Kovac, F Bauer, B Rudinsky, M Sramka

Affiliation

¹ St. Elisabeth University College of Health and Social Sciences, Bratislava, Slovakia.

PMID: 17558382

Abstract

Within a cohort of 606 cases of infective endocarditis, 263 were complicated and 99 embolizing, of them 32 to the central nervous system (CNS). Significant predictors of CNS embolisation were inappropriate therapy (p<0.01) and enterococcal etiology (p<0.01). Mortality in patients with CNS emboli was 65% what was significantly higher than in cases without embolisation - 15% (p<0.01).

MeSH terms

Adolescent
Adult
Aged
Anti-Infective Agents / therapeutic use
Bacteremia / complications
Bacteremia / microbiology
Central Nervous System Diseases / etiology*
Central Nervous System Diseases / mortality
Child
Child, Preschool
Cohort Studies
Endocarditis, Bacterial / complications*
Endocarditis, Bacterial / microbiology
Endocarditis, Bacterial / therapy
Enterococcus
Gram-Positive Bacterial Infections / complications*
Gram-Positive Bacterial Infections / therapy
Heart Failure / complications*
Heart Failure / microbiology
Humans
Intracranial Embolism / etiology*
Intracranial Embolism / mortality
Middle Aged

Substances

Anti-Infective Agents