A novel HLA-B*35 (B*3570) allele of a Caucasian family differing with one amino acid mismatch from HLA-B*3503 allele in exon 4

G Schlaf; M E Erhuma; B Seliger; J Foell; W W Altermann

doi:10.1111/j.1399-0039.2007.00845.x

A novel HLA-B35 (B3570) allele of a Caucasian family differing with one amino acid mismatch from HLA-B*3503 allele in exon 4

Tissue Antigens. 2007 Jul;70(1):72-3. doi: 10.1111/j.1399-0039.2007.00845.x.

Authors

G Schlaf¹, M E Erhuma, B Seliger, J Foell, W W Altermann

Affiliation

¹ Institute of Medical Immunology, Interbranch HLA-Laboratory, Martin Luther University Halle-Wittenberg, Magdeburger Strasse 16, D-06097 Halle, Germany.

PMID: 17559587
DOI: 10.1111/j.1399-0039.2007.00845.x

Abstract

A novel human leucocyte antigen (HLA)-B35 (HLA-B*3570) allele has been identified in a Caucasian family from Middle Europe using single allele-specific sequencing strategy. This allele is identical to the HLA-B*3503 allele except for one point mutation in exon 4 at codon 188 (CAC-->CGC), resulting in an amino acid change from histidine to arginine.

MeSH terms

Alleles*
Amino Acid Substitution
Arginine / metabolism
Base Sequence
Child
Codon
Exons*
Family*
Female
HLA-B Antigens / chemistry
HLA-B Antigens / genetics*
Haplotypes
Humans
Molecular Sequence Data
Neuroblastoma / pathology
Point Mutation
Sequence Analysis, DNA
White People / genetics*

Substances

Codon
HLA-B Antigens
Arginine

Associated data

GENBANK/AM410967