Structure of a colitose-containing O-polysaccharide from the lipopolysaccharide of Providencia alcalifaciens O6

Carbohydr Res. 2007 Oct 15;342(14):2144-8. doi: 10.1016/j.carres.2007.05.010. Epub 2007 May 18.

Abstract

The O-polysaccharide was isolated by mild acid degradation of the lipopolysaccharide of Providencia alcalifaciens O6 and studied by sugar and methylation analysis, selective hydrolytic removal of 3,6-dideoxy-L-xylo-hexose (colitose, Col), (1)H and (13)C NMR spectroscopy, including 2D (1)H,(1)H COSY, TOCSY, ROESY and H-detected (1)H,(13)C HSQC and HMBC experiments. The polysaccharide was found to have a branched pentasaccharide repeating unit with the following structure: [see text] Remarkably, the trisaccharide side chain of the O6-polysaccharide represents a colitose ('3-deoxy-L-fucose') analogue of the H type 1 (precursor) antigenic determinant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbohydrate Sequence
  • Deoxy Sugars / chemistry*
  • Lipopolysaccharides / chemistry
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • O Antigens / chemistry*
  • O Antigens / isolation & purification
  • Providencia / chemistry*

Substances

  • Deoxy Sugars
  • Lipopolysaccharides
  • O Antigens
  • colitose