Abstract
We describe a young woman with progressive cognitive and neurological deficits during a parietal lobe status epilepticus (SE). Ictal FDG-PET showed left parietal lobe hypermetabolism and frontal lobe hypometabolism with concomitant EEG slowing. Cognitive and neurological deficits fully reversed more than 1 year after seizure remission, and were associated with normalization of FDG-PET and EEG. Our findings suggest that ictal hypometabolism and EEG delta activity at a distance from the epileptic focus were seizure-related phenomena, possibly representing inhibition in seizure propagation pathways, which could be responsible for the epileptic encephalopathy.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anticonvulsants / therapeutic use
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Cognition Disorders / diagnosis*
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Cognition Disorders / diagnostic imaging
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Cognition Disorders / physiopathology*
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Delta Rhythm / statistics & numerical data
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Electroencephalography / statistics & numerical data
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Female
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Fluorodeoxyglucose F18
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Follow-Up Studies
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Frontal Lobe / metabolism*
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Frontal Lobe / physiopathology*
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Humans
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Neural Inhibition / physiology
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Neural Pathways / metabolism
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Neural Pathways / physiopathology
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Neuropsychological Tests
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Parietal Lobe / diagnostic imaging
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Parietal Lobe / metabolism*
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Parietal Lobe / physiopathology*
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Positron-Emission Tomography / statistics & numerical data
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Status Epilepticus / diagnosis*
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Status Epilepticus / drug therapy
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Status Epilepticus / physiopathology*
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Time Factors
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Treatment Outcome
Substances
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Anticonvulsants
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Fluorodeoxyglucose F18