Abstract
Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and colistin and carried the bla(KPC-3) gene, while almost all other clones carried the bla(KPC-2) gene. This rapid dissemination of KPC outside the United States is worrisome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Carbapenems / metabolism
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Carbapenems / pharmacology*
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Hospitals*
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Humans
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Israel / epidemiology
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Klebsiella Infections / epidemiology*
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / isolation & purification
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Microbial Sensitivity Tests
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Molecular Epidemiology
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beta-Lactam Resistance*
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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beta-lactamase KPC-2
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beta-Lactamases
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beta-lactamase KPC-3, Klebsiella pneumoniae