Abstract
Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / pharmacology*
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Artemisinins / chemistry
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Artemisinins / pharmacology*
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Eukaryota / classification
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Eukaryota / drug effects*
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Heterocyclic Compounds, 1-Ring / chemistry
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Heterocyclic Compounds, 1-Ring / pharmacology*
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Iron / metabolism
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Parasitic Sensitivity Tests
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Peroxides / chemistry*
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Peroxides / pharmacology
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Plasmodium falciparum / drug effects
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Sesquiterpenes / chemistry
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Sesquiterpenes / pharmacology*
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Spiro Compounds / chemistry
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Spiro Compounds / pharmacology*
Substances
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Antimalarials
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Artemisinins
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Heterocyclic Compounds, 1-Ring
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Peroxides
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Sesquiterpenes
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Spiro Compounds
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arterolane
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deoxyartemisinin
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Iron