Abstract
Chromosomal abnormalities in Ph-negative metaphases from patients with chronic myeloid leukemia (CML) treated with imatinib have been described in some cases. Trisomy 8 is the most frequent, but monosomy 7 has also been described. However, the association of these chromosomal alterations with myelodysplasia has been scarcely reported. We report the appearance of monosomy 7 in Ph-negative cells, associated with severe dysplasia, in two patients with CML treated with imatinib, with a different outcome: one with a transient evolution and the other evolving to acute myeloid leukemia.
2007 Wiley-Liss, Inc
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / therapeutic use*
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Benzamides
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Chromosomes, Human, Pair 7*
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Disease Progression
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Fatal Outcome
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Humans
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Imatinib Mesylate
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
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Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis
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Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics*
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Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / pathology
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Male
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Middle Aged
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Monosomy / genetics*
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Monosomy / immunology
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Myelodysplastic Syndromes / genetics*
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Piperazines / therapeutic use*
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Pyrimidines / therapeutic use*
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Treatment Outcome
Substances
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Antineoplastic Agents
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Benzamides
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Piperazines
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Pyrimidines
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Imatinib Mesylate