The objective of this study was to understand musculoskeletal pain events and the use of health care services, including complementary and alternative medicine (CAM) in Japan. We conducted a prospective cohort study for a 1-month period using a health diary in a random sample of adults. Of the 2,226 adults, 1,065 (48%) reported new musculoskeletal pain events. The mean number of events was 3.6 in 1 month. Back, neck and knee pain were among the most frequent. The episodes of various musculoskeletal pain events was different by gender, age, city size of living, income, job status, education, body mass index, and baseline quality of life. The individuals with musculoskeletal pain were more likely to use CAM than to visit physicians. Musculoskeletal pain is very common and the individuals with musculoskeletal pain are more likely to use CAM than to visit physicians in Japan.