Multifocal Scedosporium apiospermum spondylitis in a cystic fibrosis patient

S Guignard; D Hubert; B Dupont; P Anract; D Alioua; H Guerini; A Paugam; M Dougados

doi:10.1016/j.jcf.2007.05.003

Multifocal Scedosporium apiospermum spondylitis in a cystic fibrosis patient

J Cyst Fibros. 2008 Jan;7(1):89-91. doi: 10.1016/j.jcf.2007.05.003. Epub 2007 Jun 13.

Authors

S Guignard¹, D Hubert, B Dupont, P Anract, D Alioua, H Guerini, A Paugam, M Dougados

Affiliation

¹ Université René Descartes, Hôpital Cochin APHP, service de rhumatologie B, 27 rue du faubourg Saint Jacques, 75679 Paris cedex 14, France.

PMID: 17567545
DOI: 10.1016/j.jcf.2007.05.003

Abstract

We report the first case of multifocal Scedosporium apiospermum spondylitis in a cystic fibrosis patient. The infection, which occurred during voriconazole prophylaxis, disseminated contiguously from the base of the left lung and pleura and spread to vertebrae via the epidural space. S. apiospermum osteoarticular infections are rare, and are difficult to diagnose and cure because of their resistance to anti-fungal drugs.

Publication types

Case Reports

MeSH terms

Adult
Antifungal Agents / therapeutic use*
Caspofungin
Cystic Fibrosis / complications*
Cystic Fibrosis / microbiology
Drug Therapy, Combination
Echinocandins / therapeutic use
Humans
Immunocompromised Host
Lipopeptides
Male
Mycetoma / drug therapy*
Pleurisy / complications*
Pleurisy / microbiology
Pyrimidines / therapeutic use
Scedosporium / drug effects
Scedosporium / pathogenicity*
Spondylitis / complications
Spondylitis / drug therapy
Spondylitis / microbiology*
Thoracic Vertebrae / microbiology*
Triazoles / therapeutic use
Voriconazole

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Pyrimidines
Triazoles
Caspofungin
Voriconazole