Abstract
Two series of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)-quinoxalines 2a-l and 2-(quinoxalin-2-yl)-isothioureas 3a-l were prepared. All the test compounds 2a-l and 3a-l were screened in vitro, in a RIN5F cell-based assay for glucose-dependent insulinotropic activity. A significant concentration and glucose-dependent insulin secretion effect was seen with compounds 2a-l and the insulinotropic activity of compound 2l was found to be identical to that of the standard compound (6,7-dichloro-2-trifluromethyl-3-(5-methyl-1,3,4-thiadiazo-2-ylsulfanyl)-quinoxaline (1)).
MeSH terms
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Animals
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Cell Line, Tumor
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Dose-Response Relationship, Drug
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Hypoglycemic Agents / chemical synthesis*
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Imidazoles / pharmacology
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Insulin / metabolism*
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Insulin Secretion
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Insulin-Secreting Cells / drug effects
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Insulin-Secreting Cells / metabolism
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Quinoxalines / chemical synthesis*
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Quinoxalines / chemistry
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Quinoxalines / pharmacology
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Rats
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Stereoisomerism
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Structure-Activity Relationship
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Sulfones / chemical synthesis*
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Sulfones / chemistry
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Sulfones / pharmacology
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Thiourea / analogs & derivatives*
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Thiourea / chemical synthesis*
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Thiourea / chemistry
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Thiourea / pharmacology
Substances
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Hypoglycemic Agents
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Imidazoles
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Insulin
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Quinoxalines
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Sulfones
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Thiourea