Chronic urticaria is a disease with numerous aetiologies. In case of blood hypereosinophilia a parasitosis is probable an should be mentioned. Infections with echinococcus and helminths can cause IgE mediated release of histamine. Different cytokines are involved and lead to chronic urticaria as well. There are only a few case repoorts about chronic urticaria caused by amoebiasis. The transmission of amoebas is faeco oral and the pathogen can be detected with stool examinations or with testing of antigens or molecular methods. This case showed a remission of chronic urticaria after treatment of the amboebiasis with metronidazole and paromomycine. Therfore a direct causal connection of the amoebiasis and chronic urticaria can be assumed.