Abstract
A 75-year-old man was admitted to our hospital in October, 2005 for examination of pre-diagnosed pancytopenia. His bone marrow showed myeloid dysplasia, and 30.4% of the nucleated cells were blasts. Our diagnosis was acute myelogenous leukemia with multilineage myelodysplasia (AML with MLD; WHO classification). A direct Coombs test proved positive, and the platelet-associated IgG (PA-IgG) level was elevated. After treatment with CAG (Ara-C + ACR + G-CSF), complete remission was obtained, showing negative on the direct Coombs test with PA-IgG levels returned to normal. The patient subsequently relapsed, testing positive on the direct Coombs test and experiencing a re-elevation of PA-IgG levels. We report here a first case of AML with MLD, direct Coombs test and PA-IgG assay.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aclarubicin / administration & dosage
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Blood Platelets / immunology*
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Coombs Test*
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Cytarabine / administration & dosage
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Granulocyte Colony-Stimulating Factor / administration & dosage
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Humans
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Immunoglobulin G / blood*
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Leukemia, Myeloid, Acute / blood
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Leukemia, Myeloid, Acute / complications*
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Leukemia, Myeloid, Acute / diagnosis*
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Leukemia, Myeloid, Acute / drug therapy
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Male
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Myelodysplastic Syndromes / blood
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Myelodysplastic Syndromes / complications*
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Myelodysplastic Syndromes / diagnosis*
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Myelodysplastic Syndromes / drug therapy
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Pancytopenia / etiology
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Prednisolone / administration & dosage
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Treatment Outcome
Substances
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Immunoglobulin G
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Cytarabine
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Granulocyte Colony-Stimulating Factor
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Aclarubicin
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Prednisolone