Adenoid basal carcinoma arising in the cervical polyp: an immunohistochemical study of stromal cells

Med Mol Morphol. 2007 Jun;40(2):112-4. doi: 10.1007/s00795-006-0343-6. Epub 2007 Jun 18.

Abstract

Adenoid basal carcinomas of the uterine cervix are uncommon neoplasms and generally run a favorable clinical course. Although it is well known that these tumors do not evoke the stromal reaction, we immunohistochemically examined a stromal reaction in a case of adenoid basal carcinoma. A 40-year-old woman was found to have a cervical polyp during a medical checkup and underwent polypectomy. Histological examination revealed the finding of adenoid basal carcinoma. Immunohistochemically, a smaller number of CD34-positive and CD31-negative stromal cells, namely fibroblasts, in the stroma of tumor center than in normal cervical stroma were observed. On the other hand, alpha-smooth muscle actin-positive and h-caldesmon-negative stromal cells, namely myofibroblasts, were completely absent in the stroma of tumor center. Finally, our preliminary report suggests that the decrease of CD34-positive fibroblasts in adenoid basal carcinoma may show an early stromal reaction to tumor invasion. Gynecologists and pathologists should bear in mind that adenoid basal carcinoma may arise in a cervical polyp.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD34 / metabolism
  • Biomarkers, Tumor / metabolism*
  • Carcinoma, Adenoid Cystic / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Neoplasms, Basal Cell / pathology*
  • Polyps / pathology*
  • Stromal Cells / metabolism*
  • Uterine Cervical Neoplasms / pathology*

Substances

  • Antigens, CD34
  • Biomarkers, Tumor