TRIB1 overexpression in acute myeloid leukemia

Benno Röthlisberger; Marc Heizmann; Mario J Bargetzi; Andreas R Huber

doi:10.1016/j.cancergencyto.2007.03.003

TRIB1 overexpression in acute myeloid leukemia

Cancer Genet Cytogenet. 2007 Jul 1;176(1):58-60. doi: 10.1016/j.cancergencyto.2007.03.003.

Authors

Benno Röthlisberger¹, Marc Heizmann, Mario J Bargetzi, Andreas R Huber

Affiliation

¹ Center of Laboratory Medicine, Kantonsspital Aarau, CH-5000 Arau, Switzerland.

PMID: 17574965
DOI: 10.1016/j.cancergencyto.2007.03.003

Abstract

In this report, an AML patient with an additional ring chromosome 8 was investigated in detail. Fluorescence in situ hybridization showed high amplification of MYC on the additional ring chromosome and signals on both chromosome 8 homologues. In addition to the amplified segment from 8q24, no additional chromosomal aberration was found by array comparative genomic hybridization. Real-time reverse-transcription polymerase chain reaction analysis revealed that MYC and TRIB1 (a gene also localized on 8q24, close to MYC) were clearly overexpressed when compared with healthy donors, acute myeloid leukemia patients without MYC amplification, chronic myeloid leukemia patients, and acute lymphatic leukemia patients. These results may indicate a key role of TRIB1 (and MYC) overexpression in the pathogenesis of a certain AML subtype.

Publication types

Case Reports

MeSH terms

Chromosomes, Human, Pair 8*
Female
Gene Amplification*
Genes, myc*
Humans
In Situ Hybridization, Fluorescence
Intracellular Signaling Peptides and Proteins / genetics*
Leukemia, Myeloid, Acute / genetics*
Middle Aged
Protein Serine-Threonine Kinases / genetics*
Ring Chromosomes*

Substances

Intracellular Signaling Peptides and Proteins
TRIB1 protein, human
Protein Serine-Threonine Kinases