Abstract
Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 days postinfection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal*
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Antiviral Agents*
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Blotting, Western
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Chemokines / metabolism
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Cinnamates / pharmacology*
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Cytokines / metabolism
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Depsides / pharmacology*
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Encephalitis Virus, Japanese / drug effects
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Encephalitis, Japanese / drug therapy*
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Encephalitis, Japanese / pathology
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Encephalitis, Japanese / virology*
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Mice
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Rosmarinic Acid
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antiviral Agents
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Chemokines
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Cinnamates
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Cytokines
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Depsides