Cardiovascular profile of the canine torsades de pointes arrhythmia model assessed by echocardiographic and haemodynamic methods

Basic Clin Pharmacol Toxicol. 2007 Jul;101(1):35-40. doi: 10.1111/j.1742-7843.2007.00071.x.

Abstract

Chronic atrioventricular block dogs have been established as an in vivo model of drug-induced torsades de pointes arrhythmias. We compared the cardiovascular profile of the canine model with that of sham-operated animals using echocardiographic and haemodynamic methods. In the echocardiographic study, the larger diameters of the left atria, inferior vena cava and left ventricle in end-diastole in addition to greater fractional shortening, end-diastolic volume, stroke volume and ejection fraction were more often detected in the chronic atrioventricular block dogs than in the sham-operated animals. During haemodynamic examination, lower cardiac output and higher pulmonary capillary wedge pressure were detected in chronic atrioventricular block dogs more than in sham-operated animals; however, these changes were within the physiological limits, and the results suggest that the chronic atrioventricular block dogs have a pathophysiological profile of chronic compensated heart failure.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure
  • Cardiac Output
  • Disease Models, Animal
  • Dogs
  • Echocardiography
  • Electrocardiography
  • Female
  • Heart / physiopathology*
  • Heart Block / physiopathology*
  • Heart Rate
  • Male
  • Stroke Volume
  • Torsades de Pointes / physiopathology*