Synthesis and antiviral evaluation of AZT analogues with A spacer arm between glucidic and base moieties. Part II

Vincent Roy; Rachida Zerrouki; Pierre Krausz; Géraldine Laumond; Anne Marie Aubertin

doi:10.1080/15257770701426153

Synthesis and antiviral evaluation of AZT analogues with A spacer arm between glucidic and base moieties. Part II

Nucleosides Nucleotides Nucleic Acids. 2007;26(5):413-21. doi: 10.1080/15257770701426153.

Authors

Vincent Roy¹, Rachida Zerrouki, Pierre Krausz, Géraldine Laumond, Anne Marie Aubertin

Affiliation

¹ Université de Limoges, Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Limoges, France.

PMID: 17578740
DOI: 10.1080/15257770701426153

Abstract

This article describes the synthesis of a series of AZT analogues bearing an acyclic chain between the sugar and the base moieties is described. These new compounds were readily obtained using microwave irradiation. The compounds were characterized by (1)H NMR and IR spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry*
Antiviral Agents / pharmacology
Cell Line, Transformed
Cell Survival / drug effects
HIV-1 / drug effects
Humans
Models, Chemical
Molecular Structure
Nucleosides / chemistry*
Zidovudine / chemical synthesis
Zidovudine / chemistry*
Zidovudine / pharmacology

Substances

Antiviral Agents
Nucleosides
Zidovudine