Preparation of functionalized aryl- and heteroarylpyridazines by nickel-catalyzed electrochemical cross-coupling reactions

J Org Chem. 2007 Jul 20;72(15):5631-6. doi: 10.1021/jo070429+. Epub 2007 Jun 20.

Abstract

A general efficient electrochemical method for the preparation of aryl- and heteroarylpyridazines in a nickel-catalyzed cross-coupling reaction of 3-chloro-6-methoxypyridazine and 3-chloro-6-methylpyridazine with a range of functionalized aryl or heteroaryl halides is reported.

MeSH terms

  • Catalysis
  • Electrochemistry / methods*
  • Nickel / chemistry*
  • Pyridazines / chemistry*

Substances

  • Pyridazines
  • Nickel