APRIL in the intestine: a good destination for immunoglobulin A(2)

Immunity. 2007 Jun;26(6):755-7. doi: 10.1016/j.immuni.2007.06.003.

Abstract

Immunoglobulin A (IgA) confers mucosal protection against bacteria in the intestine. In this issue, He et al. (2007) find that bacterial molecules promote IgA(2) generation via the cytokine APRIL, produced by intestinal epithelial and dendritic cells.

Publication types

  • Comment

MeSH terms

  • Bacteria / immunology*
  • Bacterial Proteins / immunology
  • Humans
  • Immunoglobulin A / immunology*
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / microbiology
  • Intestines / immunology
  • Intestines / microbiology
  • Tumor Necrosis Factor Ligand Superfamily Member 13 / physiology*

Substances

  • Bacterial Proteins
  • Immunoglobulin A
  • Tumor Necrosis Factor Ligand Superfamily Member 13