Abstract
Typically, malignant melanoma has wild-type p53, and yet this cancer proliferates. S100B, which binds p53 and is up-regulated in melanoma, down-regulates wild-type p53 tumor suppressor function. Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new chemotherapeutics for melanoma.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Calcium / metabolism
-
Calcium-Binding Proteins / antagonists & inhibitors*
-
Databases, Genetic
-
Feedback, Physiological
-
Humans
-
Neoplasms / drug therapy
-
Neoplasms / metabolism
-
Nerve Growth Factors / antagonists & inhibitors*
-
Nerve Growth Factors / chemistry
-
Nerve Growth Factors / genetics
-
S100 Calcium Binding Protein beta Subunit
-
S100 Proteins / antagonists & inhibitors*
-
S100 Proteins / chemistry
-
S100 Proteins / genetics
-
Tumor Suppressor Protein p53 / genetics
-
Tumor Suppressor Protein p53 / physiology
Substances
-
Calcium-Binding Proteins
-
Nerve Growth Factors
-
S100 Calcium Binding Protein beta Subunit
-
S100 Proteins
-
S100B protein, human
-
Tumor Suppressor Protein p53
-
Calcium