Abstract
The clinical and postmortem findings of a patient with Lewy body pathology combined with multiple-system atrophy are described. When alive the patient was diagnosed as having Parkinson's disease. Pathological examination found evidence of striatonigral and olivopontocerebellar degeneration, together with Lewy bodies at a number of sites characteristic for idiopathic Parkinson's disease. Taken together, the clinical history and histological findings support the coexistence of two disease processes.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Astrocytes / pathology
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Autonomic Nervous System Diseases / diagnosis
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Autonomic Nervous System Diseases / pathology*
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Brain / pathology
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Corpus Striatum / pathology*
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Gliosis / pathology
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Humans
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Lewy Bodies / ultrastructure
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Male
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Middle Aged
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Nerve Degeneration / physiology*
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Neurologic Examination
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Olivopontocerebellar Atrophies / diagnosis
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Olivopontocerebellar Atrophies / pathology*
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Parkinson Disease / diagnosis
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Parkinson Disease / pathology*
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Substantia Nigra / pathology*