Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana

Jian-Guang Luo; Xiao-Bing Wang; Li Ma; Ling-Yi Kong

doi:10.1016/j.bmcl.2007.06.011

Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4460-3. doi: 10.1016/j.bmcl.2007.06.011. Epub 2007 Jun 8.

Authors

Jian-Guang Luo¹, Xiao-Bing Wang, Li Ma, Ling-Yi Kong

Affiliation

¹ Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.

PMID: 17587576
DOI: 10.1016/j.bmcl.2007.06.011

Abstract

An unusual new cyclic peptide with a pyrrolidine-2,5-dione unit, gypsophin (1), was isolated from Gypsophila oldhamiana. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was determined by application of the Marfey's method and the single-crystal X-ray diffraction. Compound 1 exhibited inhibitory activity against alpha-glucosidase with IC50 of 305 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Caryophyllaceae / chemistry*
Glycoside Hydrolase Inhibitors*
Models, Molecular
Peptides, Cyclic / chemistry*
Peptides, Cyclic / pharmacology*
Plant Roots / chemistry*

Substances

Glycoside Hydrolase Inhibitors
Peptides, Cyclic
gypsophin