Abstract
Zebrafish Csrp1 is a member of the cysteine- and glycine-rich protein (CSRP) family and is expressed in the mesendoderm and its derivatives. Csrp1 interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways. When csrp1 message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. In addition, cardiac bifida is induced as a consequence of defects in cardiac mesoderm cell migration. Our data highlight Csrp1 as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / physiology*
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Animals
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Carrier Proteins / biosynthesis
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Carrier Proteins / genetics
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Carrier Proteins / physiology*
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Cell Line
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Cell Movement / physiology*
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Cysteine / biosynthesis
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Cytoskeletal Proteins / physiology*
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Dishevelled Proteins
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Endoderm / chemistry
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Endoderm / cytology*
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Endoderm / metabolism
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Glycine / biosynthesis
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Heart / embryology*
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Humans
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Mesoderm / chemistry
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Mesoderm / cytology*
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Mesoderm / metabolism
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Organ Specificity / genetics
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Phosphoproteins / physiology*
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Signal Transduction / genetics
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Wnt Proteins / physiology
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Zebrafish / embryology*
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Zebrafish / genetics
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Zebrafish / physiology
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Zebrafish Proteins / biosynthesis
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Zebrafish Proteins / deficiency
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Zebrafish Proteins / genetics
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Zebrafish Proteins / physiology*
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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Cytoskeletal Proteins
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DVL2 protein, human
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Dishevelled Proteins
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Phosphoproteins
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Wnt Proteins
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Zebrafish Proteins
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ankrd6b protein, zebrafish
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csrp1a protein, zebrafish
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Cysteine
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Glycine