Abstract
The purpose of this study was to determine the effect of dutasteride on quality of life of men with lower urinary tract symptoms associated with enlarged prostate or benign prostatic hyperplasia (BPH) as measured by symptom problem index (SPI), BPH-specific interference with activities (BSIA), BPH-specific psychological well-being (BPWB) and BPH-specific lifestyle adaptations (BSLA). Data were derived from three randomized, double-blind studies conducted in 4325 men treated with placebo or dutasteride (0.5 mg/day). Primary analyses included changes from baseline in mean SPI, BSIA, BPWB and BSLA scores. Men treated with dutasteride showed significant improvements in SPI, BSIA, BPWB and BSLA scores compared with placebo.
Publication types
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Comparative Study
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Meta-Analysis
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Research Support, Non-U.S. Gov't
MeSH terms
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5-alpha Reductase Inhibitors
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Adaptation, Psychological
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Aged
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Azasteroids / therapeutic use*
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Clinical Trials, Phase III as Topic / statistics & numerical data
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Double-Blind Method
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Dutasteride
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Enzyme Inhibitors / therapeutic use*
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Humans
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Life Style
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Male
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Middle Aged
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Multicenter Studies as Topic / statistics & numerical data
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Patient Satisfaction
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Prostatic Hyperplasia / complications
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Prostatic Hyperplasia / drug therapy*
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Prostatic Hyperplasia / psychology
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Quality of Life
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Randomized Controlled Trials as Topic / statistics & numerical data
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Severity of Illness Index
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Surveys and Questionnaires
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Treatment Outcome
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Urination Disorders / drug therapy
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Urination Disorders / etiology
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Urination Disorders / psychology
Substances
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5-alpha Reductase Inhibitors
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Azasteroids
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Enzyme Inhibitors
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Dutasteride