Abstract
Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The discovery of TLRs has provided a substantial increase in the knowledge of immunologic aspects of disease pathology and is presently giving rise to new treatment strategies. This review summarizes the current knowledge on TLRs functioning in infections, their possible roles in inflammatory bowl disease and the pivotal role for TLRs in endotoxic shock, an area which is currently subject to development of a new farmakon.
MeSH terms
-
Animals
-
Bacterial Infections / drug therapy
-
Bacterial Infections / etiology
-
Bacterial Infections / immunology
-
Disaccharides / therapeutic use
-
Humans
-
Immunity, Innate
-
Inflammatory Bowel Diseases / drug therapy
-
Inflammatory Bowel Diseases / etiology
-
Inflammatory Bowel Diseases / immunology
-
Shock, Septic / drug therapy
-
Shock, Septic / etiology
-
Shock, Septic / immunology
-
Sugar Phosphates / therapeutic use
-
Toll-Like Receptors* / drug effects
-
Toll-Like Receptors* / immunology
-
Toll-Like Receptors* / physiology
-
Virus Diseases / drug therapy
-
Virus Diseases / etiology
-
Virus Diseases / immunology
Substances
-
Disaccharides
-
Sugar Phosphates
-
Toll-Like Receptors
-
eritoran