Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel

Masahiro Wada; Hiromitsu Jinno; Masakazu Ueda; Tadashi Ikeda; Masaki Kitajima; Tomohiro Konno; Junji Watanabe; Kazuhiko Ishihara

Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel

Anticancer Res. 2007 May-Jun;27(3B):1431-5.

Authors

Masahiro Wada¹, Hiromitsu Jinno, Masakazu Ueda, Tadashi Ikeda, Masaki Kitajima, Tomohiro Konno, Junji Watanabe, Kazuhiko Ishihara

Affiliation

¹ Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

PMID: 17595758

Abstract

Background: Paclitaxel (PTX) is administered as a solution in polyoxyethylated castor oil (CO) due to its low water solubility, but solvent-induced side-effects may be severe.

Materials and methods: PMB30W is a co-polymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and butyl methacrylate (BMA). Cytotoxicities of PTX in PMB30W (PTX-PMB30W) were examined in cell culture and in vivo.

Results: PTX-PMB30W and PTX in dimethyl sulfoxide showed similar toxicity in breast cancer cell lines MCF-7, SK-BR-3 and MX-1. Antitumor efficacies of PTX-PMB30W and PTX in CO (PTX-CO) were similar following weekly intraperitoneal administration of 50 mg/kg PTX in nude mice transplanted with MX-1 cells. At 200 mg/kg PTX, all animals died within 1 minute of PTX-CO administration. However, all animals receiving PTX-PBM30W survived. Ulceration occurred following subcutaneous injection of PTX-CO, but injection of PTX-PMB30W did not cause skin changes.

Conclusion: Our data suggest that PMB30W can act as an effective PTX nanotransporter.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / administration & dosage*
Antineoplastic Agents, Phytogenic / chemistry
Dimethyl Sulfoxide / chemistry
Dimethyl Sulfoxide / toxicity
Drug Carriers / administration & dosage*
Drug Carriers / chemistry
Drug Carriers / toxicity
Female
Humans
Methacrylates / administration & dosage*
Methacrylates / chemistry
Methacrylates / toxicity
Mice
Mice, Nude
Nanocapsules / administration & dosage*
Nanocapsules / chemistry
Nanocapsules / toxicity
Paclitaxel / administration & dosage*
Paclitaxel / chemistry
Phosphorylcholine / administration & dosage
Phosphorylcholine / analogs & derivatives*
Phosphorylcholine / chemistry
Phosphorylcholine / toxicity
Skin / drug effects
Skin / pathology
Skin Ulcer / chemically induced
Skin Ulcer / pathology
Xenograft Model Antitumor Assays

Substances

Antineoplastic Agents, Phytogenic
Drug Carriers
Methacrylates
Nanocapsules
Phosphorylcholine
poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate)
Paclitaxel
Dimethyl Sulfoxide