Analysis of the activation of poly(ADP-ribose) polymerase by various types of DNA

C Hengartner; J Lagueux; G G Poirier

doi:10.1139/o91-086

Analysis of the activation of poly(ADP-ribose) polymerase by various types of DNA

Biochem Cell Biol. 1991 Aug;69(8):577-80. doi: 10.1139/o91-086.

Authors

C Hengartner¹, J Lagueux, G G Poirier

Affiliation

¹ Poly (ADP-ribose) Metabolism Group, CHUL Research Center and Laval University, Ste-Foy, Que., Canada.

PMID: 1760161
DOI: 10.1139/o91-086

Abstract

In this work, we examined the activation of poly(ADP-ribose) polymerase by various types of DNA. We have found that the best activator for poly(ADP-ribose) polymerase is an octanucleotide. However, the use of a defined activated DNA is also suitable.

MeSH terms

Animals
Cattle
DNA / chemistry
Enzyme Activation
Kinetics
Oligodeoxyribonucleotides / chemistry*
Poly(ADP-ribose) Polymerases / chemistry*
Polyribonucleotides / biosynthesis*

Substances

Oligodeoxyribonucleotides
Polyribonucleotides
DNA
Poly(ADP-ribose) Polymerases