Genetic influence on contrast sensitivity in middle-aged male twins

Vision Res. 2007 Jul;47(16):2179-86. doi: 10.1016/j.visres.2007.04.017. Epub 2007 Jun 29.

Abstract

Contrast sensitivity is strongly associated with daily functioning among older adults, but the genetic and environmental contributions to this ability are unknown. Using the classical twin method, we addressed this issue by examining contrast sensitivity at five spatial frequencies (1.5-18 cycles per degree) in 718 middle-aged male twins from the Vietnam Era Twin Study of Aging (VETSA). Heritability estimates were modest (14-38%), whereas individual-specific environmental influences accounted for 62-86% of the variance. Identifying the types of individual-specific events that impact contrast sensitivity may suggest interventions to modulate this ability and thereby improve overall quality of life as adults age.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Twin Study

MeSH terms

  • Aging / physiology*
  • Contrast Sensitivity / genetics*
  • Environment
  • Health Surveys
  • Humans
  • Likelihood Functions
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Registries
  • Twins, Monozygotic*
  • Vietnam Conflict
  • Visual Acuity