Abstract
We present a case of serious treatment-refractory acyclovir- and foscarnet-resistant herpes simplex virus (HSV) type-1 orolingual infection that responded to oral cidofovir rinses after failure of acyclovir and foscarnet therapy. The use of 3% cidofovir in a saline rinse for refractory mucosal HSV infection appears promising but needs prospective evaluation.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
MeSH terms
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Administration, Topical
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Antiviral Agents / administration & dosage*
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Antiviral Agents / adverse effects
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Cidofovir
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Cytosine / administration & dosage
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Cytosine / adverse effects
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Cytosine / analogs & derivatives*
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Drug Resistance, Multiple, Viral
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Female
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Herpesvirus 1, Human / isolation & purification*
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Humans
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Immunocompromised Host
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Middle Aged
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Mouthwashes
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Organophosphonates / administration & dosage*
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Organophosphonates / adverse effects
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Stem Cell Transplantation
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Stomatitis, Herpetic / drug therapy*
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Stomatitis, Herpetic / immunology*
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Stomatitis, Herpetic / virology
Substances
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Antiviral Agents
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Mouthwashes
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Organophosphonates
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Cytosine
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Cidofovir