Abstract
We report here a straightforward preparation of various nucleoside vinyl disulfides in high yields under mild conditions using the new reaction of vinyl 2-(trimethylsilyl)ethyl (TMSE) sulfides with sulfenyl chlorides. This reaction allows the preparation of various mixed disulfides from stable silyl sulfides without formation of oxidizable and/or unstable thiols. The easy preparation of vinyl disulfides through this reaction should offer new perspectives in vinylthiol chemistry.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Disulfides / chemical synthesis*
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Disulfides / chemistry
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Molecular Structure
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Silanes / chemistry
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Sulfhydryl Compounds / chemical synthesis*
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Sulfhydryl Compounds / chemistry
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Sulfides / chemistry
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Vinyl Compounds / chemical synthesis*
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Vinyl Compounds / chemistry
Substances
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Disulfides
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Nucleosides
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Silanes
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Sulfhydryl Compounds
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Sulfides
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Vinyl Compounds