Abstract
Four new indole alkaloids were obtained from two Kopsia species, 6-oxoleuconoxine (1) from the leaf extract of K. griffithii and kopsinitarine E (2), kopsijasminine (3), and kopsonoline (4) from the stem-bark extract of K. teoi. The structures of these alkaloids were determined using NMR and MS analysis. Kopsijasminine (3) showed moderate activity in reversing multidrug resistance in vincristine-resistant KB cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Apocynaceae / chemistry*
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Drug Resistance, Neoplasm / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indole Alkaloids / pharmacology
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KB Cells
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Secologanin Tryptamine Alkaloids / chemistry
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Secologanin Tryptamine Alkaloids / isolation & purification*
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Secologanin Tryptamine Alkaloids / pharmacology
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Vincristine / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Indole Alkaloids
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Secologanin Tryptamine Alkaloids
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Vincristine