Direct lactone formation by using hypervalent iodine(III) reagents with KBr via selective C-H abstraction protocol

Toshifumi Dohi; Naoko Takenaga; Akihiro Goto; Akinobu Maruyama; Yasuyuki Kita

doi:10.1021/ol071315n

Direct lactone formation by using hypervalent iodine(III) reagents with KBr via selective C-H abstraction protocol

Org Lett. 2007 Aug 2;9(16):3129-32. doi: 10.1021/ol071315n. Epub 2007 Jul 7.

Authors

Toshifumi Dohi¹, Naoko Takenaga, Akihiro Goto, Akinobu Maruyama, Yasuyuki Kita

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871 Japan.

PMID: 17616204
DOI: 10.1021/ol071315n

Abstract

We have developed a new and reliable method for the direct construction of biologically important aryl lactones and phthalides from carboxylic and benzoic acids, using a combination of hypervalent iodine(III) reagents with KBr.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzoates / chemistry*
Bromides / chemistry*
Carboxylic Acids / chemistry*
Indicators and Reagents
Iodine / chemistry*
Lactones / chemical synthesis*
Molecular Structure
Phthalimides / chemical synthesis*
Potassium Compounds / chemistry*

Substances

Benzoates
Bromides
Carboxylic Acids
Indicators and Reagents
Lactones
Phthalimides
Potassium Compounds
Iodine
potassium bromide