Abstract
A new 26-membered macrolide, amphidinolactone B, has been isolated from a marine dinoflagellate Amphidinium sp., and the structure and relative stereochemistry were elucidated on the basis of spectroscopic data. Amphidinolactone B (1) showed modest cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Dinoflagellida / chemistry*
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Drug Screening Assays, Antitumor
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Molecular Conformation
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Nuclear Magnetic Resonance, Biomolecular
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
Substances
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Antineoplastic Agents
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Macrolides