Clarithromycin induced torsade de pointes

Ir J Med Sci. 2008 Mar;177(1):67-8. doi: 10.1007/s11845-007-0057-3. Epub 2007 Jul 7.

Abstract

Background: Clarithromycin is a commonly used macrolide antibiotic. It is known to cause QT prolongation. Medication induced QT prolongation is a major risk factor for the development of torsade de pointes.

Methods: A 79-year-old lady presented with frequent episodes of torsade de pointes following commencement of clarithromycin. This was noted to be in association with a prolongation of the QT interval.

Conclusion: Knowledge of medications which prolong the QT interval is important to minimize the risk of ventricular arrhythmias, which may lead to sudden death. This is essential in patients with a congenitally long QT interval.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Aged, 80 and over
  • Anti-Bacterial Agents / adverse effects*
  • Clarithromycin / adverse effects*
  • Electrocardiography
  • Female
  • Humans
  • Pacemaker, Artificial
  • Torsades de Pointes / chemically induced*
  • Torsades de Pointes / diagnosis
  • Torsades de Pointes / therapy

Substances

  • Adrenergic beta-Antagonists
  • Anti-Bacterial Agents
  • Clarithromycin