Abstract
Serotonin (5-HT) plays an important role as a signalling molecule in the gastrointestinal (GI) tract. The regulation of GI sensitivity via 5-HT is mediated by specific 5-HT receptor subytypes on intrinsic and extrinsic afferents. This review discusses visceral afferent hypersensitivity in irritable bowel syndrome (IBS) and the importance of 5HT(3), 5HT(4), and 5HT(2B) receptor-mediated mechanisms in the regulation of visceral sensitivity.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Enteric Nervous System* / anatomy & histology
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Enteric Nervous System* / physiology
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Humans
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Intestinal Mucosa / metabolism
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Intestines / innervation*
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Irritable Bowel Syndrome / physiopathology
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Protein Isoforms / metabolism*
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Receptors, Serotonin / metabolism*
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Serotonin / metabolism
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Signal Transduction / physiology
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Visceral Afferents / metabolism*
Substances
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Protein Isoforms
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Receptors, Serotonin
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Serotonin