Abstract
Most of the body's serotonin is released in the gut where it plays an important role in the control of gastrointestinal (GI) motility, sensitivity and muscle tone by activating different receptor subtypes. This review focuses on the known effects of selective serotonin reuptake inhibitor and serotonin receptor agonists and antagonists on the sensorimotor function of the GI tract and describes the therapeutic potential of these actions for GI motility and functional bowel disorders.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Colonic Diseases, Functional / drug therapy*
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Gastrointestinal Motility / drug effects*
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Humans
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Receptors, Serotonin / metabolism
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Selective Serotonin Reuptake Inhibitors / pharmacology
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Selective Serotonin Reuptake Inhibitors / therapeutic use
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Serotonin / metabolism
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Serotonin Agents / pharmacology
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Serotonin Agents / therapeutic use*
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Serotonin Antagonists / metabolism
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Serotonin Antagonists / therapeutic use
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Serotonin Receptor Agonists / metabolism
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Serotonin Receptor Agonists / therapeutic use
Substances
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Receptors, Serotonin
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Serotonin Agents
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Serotonin Antagonists
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Serotonin Receptor Agonists
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Serotonin Uptake Inhibitors
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Serotonin