Abstract
We report a case of diffuse large B-cell lymphoma occurring in a patient with the hyperimmunoglobulinemia E syndrome, a rare immune disorder defined by elevated immunoglobulin E levels and recurrent bacterial and fungal infections often manifesting as cold abscesses. This case further supports the notion that patients with hyperimmunoglobulinemia E have an increased risk of lymphoid malignancies and should be closely monitored. Despite a theoretic risk of severe infectious complications, chemotherapy was well tolerated and resulted in a sustained complete remission.
MeSH terms
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Adolescent
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Murine-Derived
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Cyclophosphamide / therapeutic use
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Doxorubicin / therapeutic use
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Humans
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Immunoglobulin E / blood
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Job Syndrome / complications*
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Lymphoma, Large B-Cell, Diffuse / complications*
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Lymphoma, Large B-Cell, Diffuse / drug therapy
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Lymphoma, Large B-Cell, Diffuse / pathology*
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Male
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Rituximab
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Treatment Outcome
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Vincristine / therapeutic use
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Murine-Derived
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Immunoglobulin E
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Rituximab
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Vincristine
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Doxorubicin
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Cyclophosphamide