Abstract
The bis-complexes [Cu(L(dt))(2)](OTf)(2) (1) and [Cu(L(ot))(2)](OTf)(2) (2), where L(dt) = 1-dodecyl-1,4,7-triazacyclononane, L(ot) = 1-octadecyl-1,4,7-triazacyclononane and OTf = trifluoromethanesulfonate, formed a novel class of metallo-liposomes in water that transfect pEGFP-N1 plasmids into HEK 293-T cells at 38% and 4% efficiency, respectively.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Cell Line
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Copper / chemistry*
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DNA / chemistry*
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Drug Delivery Systems
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Genetic Vectors / chemistry
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Humans
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Kidney / cytology
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Kidney / metabolism
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Liposomes / chemistry*
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Liposomes / pharmacokinetics
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Microscopy, Electron, Transmission
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Molecular Structure
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Organometallic Compounds / chemistry*
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Plasmids / chemistry*
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Transfection / methods
Substances
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Liposomes
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Organometallic Compounds
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Copper
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DNA