A novel class of metal-directed supramolecular DNA-delivery systems

Chem Commun (Camb). 2007 Jul 28:(28):2944-6. doi: 10.1039/b703201c. Epub 2007 May 9.

Abstract

The bis-complexes [Cu(L(dt))(2)](OTf)(2) (1) and [Cu(L(ot))(2)](OTf)(2) (2), where L(dt) = 1-dodecyl-1,4,7-triazacyclononane, L(ot) = 1-octadecyl-1,4,7-triazacyclononane and OTf = trifluoromethanesulfonate, formed a novel class of metallo-liposomes in water that transfect pEGFP-N1 plasmids into HEK 293-T cells at 38% and 4% efficiency, respectively.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Line
  • Copper / chemistry*
  • DNA / chemistry*
  • Drug Delivery Systems
  • Genetic Vectors / chemistry
  • Humans
  • Kidney / cytology
  • Kidney / metabolism
  • Liposomes / chemistry*
  • Liposomes / pharmacokinetics
  • Microscopy, Electron, Transmission
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Plasmids / chemistry*
  • Transfection / methods

Substances

  • Liposomes
  • Organometallic Compounds
  • Copper
  • DNA