This paper reports on an experimental study that examined the effect of a 15-week Tai Chi Chuan (TCC) exercise programme on the cardiovascular function, pulmonary function, and shoulder range of motion of persons with lower-limb disability. The experimental group comprised 22 people with lower limb disabilities and a control group of 17 participants. The experimental group was provided with 30 sessions of TCC training while the control group did not receive any intervention. After 30 sessions of TCC, significant improvements in shoulder external rotation and shoulder extension were found among participants of the experimental group. Improvements in cardiovascular and pulmonary functions were not significant. The investigators concluded that a 15-week TCC programme with mild exercise could be an effective tool for improving shoulder flexibility and muscle strength among sedentary individuals with lower-limb disabilities. Further research is recommended in examining the long-term effects of TCC on improving cardiovascular and respiratory functions in individuals with lower-limb disabilities.