Follow-up study of tuberculosis-exposed supermarket customers with negative tuberculin skin test results in association with positive gamma interferon release assay results

Willeke P J Franken; Ben F P J Koster; Ailko W J Bossink; Steven F T Thijsen; John J M Bouwman; Jaap T van Dissel; Sandra M Arend

doi:10.1128/CVI.00185-07

Follow-up study of tuberculosis-exposed supermarket customers with negative tuberculin skin test results in association with positive gamma interferon release assay results

Clin Vaccine Immunol. 2007 Sep;14(9):1239-41. doi: 10.1128/CVI.00185-07. Epub 2007 Jul 11.

Authors

Willeke P J Franken¹, Ben F P J Koster, Ailko W J Bossink, Steven F T Thijsen, John J M Bouwman, Jaap T van Dissel, Sandra M Arend

Affiliation

¹ Department of Infectious Diseases, C5-P 37, Leiden University Medical Center, P. O. Box 9600, 2300 RC Leiden, The Netherlands. [email protected]

Abstract

We report a follow-up study of 29 subjects with negative tuberculin skin test (TST) results in association with positive gamma interferon release assay (IGRA) results, mainly due to responses to CFP-10 in the T-SPOT.TB assay, during a contact investigation. One year later, 12/29 subjects (41%) had converted to positive TST results in association with negative IGRA results.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Bacterial Proteins / biosynthesis
Bacterial Proteins / immunology
Humans
Interferon-gamma / immunology*
Middle Aged
Tuberculin Test / methods*
Tuberculosis / diagnosis*
Tuberculosis / immunology
Tuberculosis / transmission

Substances

Bacterial Proteins
CFP-10 protein, Mycobacterium tuberculosis
Interferon-gamma