Abstract
Synthesis, physicochemical, and biological characterization of a series of alpha-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic-hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemical synthesis
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Aorta, Thoracic / drug effects
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Cell Proliferation / drug effects
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Macrophages / drug effects
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Mice
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Molecular Structure
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Nitric Oxide / metabolism*
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Nitric Oxide Donors / chemical synthesis
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Nitric Oxide Donors / chemistry
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Nitric Oxide Donors / pharmacology*
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Oxadiazoles / chemical synthesis*
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Oxadiazoles / chemistry
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Oxadiazoles / pharmacology
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Rats
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Rats, Inbred WKY
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Vasodilation / drug effects
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Vasodilator Agents / chemical synthesis
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Vasodilator Agents / chemistry
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Vasodilator Agents / pharmacology*
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X-Ray Diffraction
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alpha-Tocopherol / chemical synthesis*
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alpha-Tocopherol / chemistry
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alpha-Tocopherol / pharmacology
Substances
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Antioxidants
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Nitric Oxide Donors
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Oxadiazoles
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Vasodilator Agents
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furoxans
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Nitric Oxide
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alpha-Tocopherol