Abstract
Two new beta-orcinol depsidones, 1 and 2, together with 13 known compounds were isolated from the lichen Usnea articulata. The structures of 1 and 2 were elucidated by spectroscopic analyses and those of known compounds by comparison of their spectroscopic data with literature values or by direct comparison with authentic standards. Compounds 1, 2, and 5 exhibited moderate antiradical activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The depsidones 4 and 5 showed better superoxide anion scavenging activity (IC50 = 566 and 580 microM, respectively) than quercetin (IC50 = 754 microM).
MeSH terms
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology*
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Biphenyl Compounds
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Depsides / chemistry
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Depsides / isolation & purification*
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Depsides / pharmacology*
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification*
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Heterocyclic Compounds, 4 or More Rings / pharmacology
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Indonesia
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Inhibitory Concentration 50
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology*
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Molecular Structure
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Oxepins / chemistry
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Oxepins / isolation & purification*
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Oxepins / pharmacology
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Picrates / pharmacology
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Quercetin / pharmacology
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Superoxides / pharmacology
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Usnea / chemistry*
Substances
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Antioxidants
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Biphenyl Compounds
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Depsides
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Free Radical Scavengers
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Heterocyclic Compounds, 4 or More Rings
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Lactones
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Oxepins
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Picrates
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stictic acid
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Superoxides
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depsidone
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Quercetin
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1,1-diphenyl-2-picrylhydrazyl