Abstract
In vitro investigations on the combined effect of radiation and Lonidamine in one human (LXI) and two rodent cell lines (3T3, V79) showed not a clear radiosensitizing effect. Especially no inhibiting influence on the repair of potentially lethal damage of V79 cells was found. Incubation at lower pH values (6.7 to 6.9) caused no increasing effects. Lonidamine induced damage on the mitochondrial dehydrogenase-system was quantitatively measured with a modified MTT-assay.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adenocarcinoma / drug therapy
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Adenocarcinoma / radiotherapy
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Animals
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Antineoplastic Agents / pharmacology*
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Cell Line
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Combined Modality Therapy
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Cricetinae
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Cricetulus
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Humans
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Hydrogen-Ion Concentration
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Indazoles / pharmacology*
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Lung Neoplasms / drug therapy
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Lung Neoplasms / radiotherapy
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Mice
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Mitochondria / enzymology
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Oxidoreductases / analysis
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Radiotherapy Dosage
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Tetrazolium Salts
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Tumor Cells, Cultured / drug effects*
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Tumor Cells, Cultured / metabolism
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Tumor Cells, Cultured / radiation effects
Substances
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Antineoplastic Agents
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Indazoles
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Tetrazolium Salts
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Oxidoreductases
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lonidamine