[A case of recurrent esophageal cancer successfully treated with concurrent radiochemotherapy with low-dose docetaxel plus 5-FU]

Gan To Kagaku Ryoho. 2007 Jul;34(7):1119-21.
[Article in Japanese]

Abstract

A 70-year-old woman, who had undergone esophagectomy for cervical esophageal squamous cell carcinoma (pT3pN2M0, Stage III) 9 months earlier, was diagnosed as mediastinal lymph node recurrence by CT and endoscope. Patients underwent radiochemotherapy with 5 cycles of docetaxel 10 mg/m(2) on day 1 and 5-FU 250 mg/m(2) on day 1 to day 5, together with concurrent radiation (50 Gy/25 Fr) for mediastinum. After this treatment, a complete response (CR) was achieved, and there was no recurrence 9 months after the treatment. No severe adverse effects were observed. Concurrent radiochemotherapy with docetaxel and 5-FU is considered effective without serious side effects for postoperative recurrence in esophageal cancer.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / radiotherapy*
  • Carcinoma, Squamous Cell / secondary
  • Carcinoma, Squamous Cell / surgery
  • Combined Modality Therapy
  • Docetaxel
  • Drug Administration Schedule
  • Esophageal Neoplasms / drug therapy*
  • Esophageal Neoplasms / pathology
  • Esophageal Neoplasms / radiotherapy*
  • Esophageal Neoplasms / surgery
  • Esophagectomy
  • Female
  • Fluorouracil / administration & dosage
  • Humans
  • Lymph Nodes / pathology*
  • Lymphatic Metastasis
  • Mediastinum
  • Remission Induction
  • Taxoids / administration & dosage

Substances

  • Taxoids
  • Docetaxel
  • Fluorouracil