The results of the Ocular Hypertension Treatment Study (OHTS) brought to the forefront the role of central corneal thickness (CCT) as a confounder of applanation tonometry, and established CCT as an independent predictive factor for the development of glaucoma. Ophthalmologists often wonder how to use CCT in daily practice. This article reviews the current CCT literature and provides some basic guidance to clinicians wishing to integrate CCT into their care of glaucoma patients.