Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX

Mol Cell. 2007 Jul 20;27(2):178-179. doi: 10.1016/j.molcel.2007.07.005.

Abstract

In a step toward clarifying how acute viral infections provoke the host DNA damage response, Tarakanova et al. (2007) characterized a gamma-herpesvirus protein, which phosphorylates histone H2AX during infection, suggesting that the virus actively initiates and benefits from the host DNA damage response.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA Damage*
  • Gammaherpesvirinae / genetics*
  • Gammaherpesvirinae / metabolism*
  • Gammaherpesvirinae / pathogenicity
  • Herpesviridae Infections / metabolism
  • Herpesviridae Infections / virology
  • Histones / metabolism*
  • Mice
  • Models, Biological
  • Open Reading Frames
  • Phosphorylation
  • Viral Proteins / genetics
  • Viral Proteins / metabolism
  • Virus Replication / physiology*

Substances

  • Histones
  • Viral Proteins