Abstract
Although chemotherapy remains among the best treatment options for most cancers, adjuvant therapies such as dendritic cell (DC)-based immunotherapy have been added to treatment protocols to destroy residual tumour cells. Combination treatment with low-dose temozolomide (TMZ) chemotherapy followed by vaccination with TAT-survivin-pulsed DCs enhanced T-cell responses specific for survivin and improved survival rate, as compared with DC alone or TMZ alone. Moreover, antigen-specific immunity appears to be mediated by CD8(+) T cells, as determined by in vitro T-cell subset depletion. These studies demonstrated that a combination of low-dose TMZ chemotherapy and TAT-based DC immunotherapy may be a novel strategy for safe and effective treatment of malignant gliomas.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Alkylating / therapeutic use*
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Apoptosis Regulatory Proteins / immunology
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CD8-Positive T-Lymphocytes / immunology
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Cancer Vaccines / therapeutic use*
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Cell Proliferation
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Combined Modality Therapy
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Dacarbazine / analogs & derivatives*
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Dacarbazine / therapeutic use
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Dendritic Cells / transplantation*
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Female
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Glioma / drug therapy
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Glioma / immunology
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Glioma / therapy*
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Immunity, Cellular
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Inhibitor of Apoptosis Proteins
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Mice
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Mice, Inbred C57BL
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Microtubule-Associated Proteins / immunology
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Neoplasm Proteins / immunology
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Recombinant Fusion Proteins / immunology
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Repressor Proteins
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Spleen / immunology
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Survival Analysis
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Survivin
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Temozolomide
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Transduction, Genetic
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Treatment Outcome
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tat Gene Products, Human Immunodeficiency Virus / immunology
Substances
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Antineoplastic Agents, Alkylating
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Apoptosis Regulatory Proteins
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Birc5 protein, mouse
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Cancer Vaccines
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HIV-TAT-survivin (T34A) protein
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Inhibitor of Apoptosis Proteins
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Microtubule-Associated Proteins
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Neoplasm Proteins
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Recombinant Fusion Proteins
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Repressor Proteins
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Survivin
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tat Gene Products, Human Immunodeficiency Virus
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Dacarbazine
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Temozolomide