An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir

Chem Commun (Camb). 2007 Aug 14:(30):3183-5. doi: 10.1039/b703295a. Epub 2007 May 25.

Abstract

A novel synthetic route towards oseltamivir, an influenza neuraminidase inhibitor, has been achieved employing a cationic iron carbonyl complex, providing an alternate pathway with the potential to access diverse analogues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Carbon Monoxide / chemistry
  • Cyclohexenes / chemistry
  • Enzyme Inhibitors / chemical synthesis
  • Iron / chemistry*
  • Neuraminidase / antagonists & inhibitors*
  • Organometallic Compounds / chemistry*
  • Oseltamivir / chemical synthesis*

Substances

  • Antiviral Agents
  • Cyclohexenes
  • Enzyme Inhibitors
  • Organometallic Compounds
  • Oseltamivir
  • Carbon Monoxide
  • Iron
  • Neuraminidase