Abstract
An 18-month epidemiologic investigation of Candida bloodstream infections in a Singapore hospital identified 52 candidemic patients: 36% of whose infections were caused by C. tropicalis, 29% were due to C. albicans, 10% with C. parapsilosis and 21% involved C. glabrata. A predominant clonal C. tropicalis strain was demonstrated. No association with ICU stay, prior exposure to fluconazole/broad-spectrum antibiotics or increased mortality was found in this apparent shift towards non-C. albicans Candida species as the primary agents of candidemia.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Antifungal Agents / pharmacology
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Candida / classification
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Candida / genetics
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Candida / isolation & purification
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Candida tropicalis / classification
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Candida tropicalis / genetics
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Candida tropicalis / isolation & purification*
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Candidiasis / epidemiology
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Candidiasis / microbiology
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Child
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Child, Preschool
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DNA, Fungal / analysis
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Female
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Fluconazole / pharmacology
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Fungemia / epidemiology*
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Fungemia / microbiology
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Hospitals, Teaching*
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Humans
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Infant
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Molecular Epidemiology
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Random Amplified Polymorphic DNA Technique
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Singapore / epidemiology
Substances
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Antifungal Agents
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DNA, Fungal
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Fluconazole