Abstract
Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / immunology*
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Chronic Disease
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Cytokines / metabolism*
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Cytotoxicity, Immunologic
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Humans
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Immunologic Memory*
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Lymphocytic Choriomeningitis / immunology*
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Lymphocytic Choriomeningitis / virology
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Lymphocytic choriomeningitis virus / immunology
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Receptors, Antigen, T-Cell / immunology
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Receptors, Antigen, T-Cell / metabolism
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T-Lymphocyte Subsets / immunology
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Virus Diseases / immunology*
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Virus Diseases / virology
Substances
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Cytokines
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Receptors, Antigen, T-Cell